Joseph W S
Pennsylvania College of Podiatric Medicine, Philadelphia 19107, USA.
J Am Podiatr Med Assoc. 1997 Nov;87(11):520-31. doi: 10.7547/87507315-87-11-520.
The author discusses the new oral antifungal agents for the treatment of onychomycosis. The history, mechanisms of action, efficacies, dosing, safety profiles, and costs of itraconazole, terbinafine, and fluconazole are reviewed. The author emphasizes that use of these effective antifungals represents an important paradigm shift for podiatric physicians away from the palliative therapy of nail debridement to a potentially curative treatment.
作者讨论了用于治疗甲癣的新型口服抗真菌药物。对伊曲康唑、特比萘芬和氟康唑的历史、作用机制、疗效、给药剂量、安全性概况及成本进行了综述。作者强调，使用这些有效的抗真菌药物对于足病医生而言是一个重要的模式转变，从指甲清创的姑息治疗转向了潜在的治愈性治疗。
