• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

人乳头瘤病毒16型和18型E2氨基酸变体分析及其与病变分级和HLA DR/DQ类型的关联。

Analysis of E2 amino acid variants of human papillomavirus types 16 and 18 and their associations with lesion grade and HLA DR/DQ type.

作者信息

Terry G, Ho L, Cuzick J

机构信息

Department of Mathematics, Statistics and Epidemiology, Imperial Cancer Research Fund, London, UK.

出版信息

Int J Cancer. 1997 Nov 27;73(5):651-5. doi: 10.1002/(sici)1097-0215(19971127)73:5<651::aid-ijc7>3.0.co;2-w.

DOI:10.1002/(sici)1097-0215(19971127)73:5<651::aid-ijc7>3.0.co;2-w
PMID:9398041
Abstract

Human papillomavirus (HPV) 16 and HPV 18 E2 amino acid variants and host HLA DR/DQ haplotypes have been identified by direct nucleic acid sequencing from cervical scrapes. HPV16 E2 variants co-segregate with a nucleotide variant at nt350 (in E6), which previously has been associated with persistent infections. Both HPV16 and HPV18 E2 variants occur relatively more frequently in individuals with HLA DR/DQ haplotypes 0401/0301 and 1101/0301 but are not related to lesion grade.

摘要

通过对宫颈刮片进行直接核酸测序，已鉴定出人类乳头瘤病毒（HPV）16型和18型的E2氨基酸变体以及宿主HLA DR/DQ单倍型。HPV16 E2变体与nt350（E6中）的一个核苷酸变体共分离，该核苷酸变体先前与持续性感染有关。HPV16和HPV18 E2变体在HLA DR/DQ单倍型为0401/0301和1101/0301的个体中出现的频率相对较高，但与病变分级无关。

相似文献

1
Analysis of E2 amino acid variants of human papillomavirus types 16 and 18 and their associations with lesion grade and HLA DR/DQ type.人乳头瘤病毒16型和18型E2氨基酸变体分析及其与病变分级和HLA DR/DQ类型的关联。
Int J Cancer. 1997 Nov 27;73(5):651-5. doi: 10.1002/(sici)1097-0215(19971127)73:5<651::aid-ijc7>3.0.co;2-w.
2
Host and viral genetics and risk of cervical cancer: a review.宿主与病毒遗传学及宫颈癌风险：综述
Virus Res. 2002 Nov;89(2):229-40. doi: 10.1016/s0168-1702(02)00191-0.
3
Sequence variation and physical state of human papillomavirus type 16 cervical cancer isolates from Australia and New Caledonia.来自澳大利亚和新喀里多尼亚的16型人乳头瘤病毒宫颈癌分离株的序列变异和物理状态
Int J Cancer. 2002 Feb 20;97(6):868-74. doi: 10.1002/ijc.10103.
4
HPV 16 infection and progression of cervical intra-epithelial neoplasia: analysis of HLA polymorphism and HPV 16 E6 sequence variants.人乳头瘤病毒16型感染与宫颈上皮内瘤变的进展：人类白细胞抗原多态性及人乳头瘤病毒16型E6序列变异分析
Int J Cancer. 1998 Oct 5;78(2):166-71. doi: 10.1002/(sici)1097-0215(19981005)78:2<166::aid-ijc8>3.0.co;2-x.
5
Association between human papillomavirus 16 E6 variants and human leukocyte antigen class I polymorphism in cervical cancer of Swedish women.瑞典女性宫颈癌中人乳头瘤病毒16 E6变异体与人类白细胞抗原I类多态性之间的关联
Hum Immunol. 2003 May;64(5):538-42. doi: 10.1016/s0198-8859(03)00033-8.
6
HLA DQ-DR haplotype and susceptibility to cervical carcinoma: indications of increased risk for development of cervical carcinoma in individuals infected with HPV 18.人类白细胞抗原DQ-DR单倍型与宫颈癌易感性：感染人乳头瘤病毒18型个体患宫颈癌风险增加的指征
Tissue Antigens. 1996 Jul;48(1):32-7. doi: 10.1111/j.1399-0039.1996.tb02602.x.
7
Cervical lesions are associated with human papillomavirus type 16 intratypic variants that have high transcriptional activity and increased usage of common mammalian codons.宫颈病变与人乳头瘤病毒16型的亚型变体有关，这些变体具有高转录活性且增加了常见哺乳动物密码子的使用频率。
J Gen Virol. 2000 Jun;81(Pt 6):1517-27. doi: 10.1099/0022-1317-81-6-1517.
8
Asian-american variants of human papillomavirus type 16 have extensive mutations in the E2 gene and are highly amplified in cervical carcinomas.人乳头瘤病毒16型的亚裔美国人变体在E2基因中有大量突变，并且在宫颈癌中高度扩增。
Int J Cancer. 1999 Nov 12;83(4):449-55. doi: 10.1002/(sici)1097-0215(19991112)83:4<449::aid-ijc3>3.0.co;2-0.
9
Suppression of tumorigenesis by transcription units expressing the antisense E6 and E7 messenger RNA (mRNA) for the transforming proteins of the human papilloma virus and the sense mRNA for the retinoblastoma gene in cervical carcinoma cells.在宫颈癌细胞中，通过表达针对人乳头瘤病毒转化蛋白的反义E6和E7信使核糖核酸（mRNA）以及视网膜母细胞瘤基因的正义mRNA的转录单位来抑制肿瘤发生。
Cancer Gene Ther. 1995 Mar;2(1):19-32.
10
HLA DR-DQ associations with cervical carcinoma show papillomavirus-type specificity.人白细胞抗原DR-DQ与宫颈癌的关联具有乳头瘤病毒类型特异性。
Nat Genet. 1994 Feb;6(2):157-62. doi: 10.1038/ng0294-157.

引用本文的文献

1
Interaction between polymorphisms of the human leukocyte antigen and HPV-16 variants on the risk of invasive cervical cancer.人类白细胞抗原多态性与HPV - 16变体之间的相互作用对浸润性宫颈癌风险的影响
BMC Cancer. 2008 Aug 22;8:246. doi: 10.1186/1471-2407-8-246.
2
Human papillomavirus type 16 integration in cervical carcinoma in situ and in invasive cervical cancer.人乳头瘤病毒16型在宫颈原位癌和浸润性宫颈癌中的整合。
J Clin Microbiol. 2006 May;44(5):1755-62. doi: 10.1128/JCM.44.5.1755-1762.2006.
3
Diversifying selection in human papillomavirus type 16 lineages based on complete genome analyses.
基于全基因组分析的16型人乳头瘤病毒谱系中的多样化选择
J Virol. 2005 Jun;79(11):7014-23. doi: 10.1128/JVI.79.11.7014-7023.2005.
4
Variation in the E2-binding domain of HPV 16 is associated with high-grade squamous intraepithelial lesions of the cervix.人乳头瘤病毒16型E2结合结构域的变异与宫颈高级别鳞状上皮内病变相关。
Br J Cancer. 2001 Apr 20;84(8):1058-63. doi: 10.1054/bjoc.2001.1695.
5
Association between high-risk HPV types, HLA DRB1* and DQB1* alleles and cervical cancer in British women.英国女性高危型人乳头瘤病毒（HPV）类型、人类白细胞抗原DRB1*和DQB1*等位基因与宫颈癌之间的关联
Br J Cancer. 2000 Apr;82(7):1348-52. doi: 10.1054/bjoc.1999.1103.