Allen M, Kalantari M, Ylitalo N, Pettersson B, Hagmar B, Scheibenpflug L, Johansson B, Petterson U, Gyllensten U
Department of Medical Genetics, Biomedical Center, University of Uppsala, Sweden.
Tissue Antigens. 1996 Jul;48(1):32-7. doi: 10.1111/j.1399-0039.1996.tb02602.x.
The association of HLA class II DQB1 and DRB1 alleles with the development of cervical carcinoma was studied in 150 Swedish patients using PCR-based HPV and HLA typing. The association of cervical carcinoma with alleles encoding the DQ3 antigen, previously found among German and Norwegian patients, was not observed in the Swedish patients. Five DQ-DR haplotypes were indicated to be positively associated with development of cervical carcinoma in the Swedish patients. Two of these HLA associations were specific for HPV 18 infected patients, suggesting that the ability of the oncogenic HPV 18 to cause more rapid-transit tumors than other high risk HPV types may be due to a deficiency in antigen presentation by the HLA molecules encoded by carried on these haplotypes.
利用基于聚合酶链反应（PCR）的人乳头瘤病毒（HPV）和人类白细胞抗原（HLA）分型技术，对150名瑞典患者进行研究，以探讨HLA II类DQB1和DRB1等位基因与宫颈癌发生之间的关联。此前在德国和挪威患者中发现的宫颈癌与编码DQ3抗原的等位基因之间的关联，在瑞典患者中未观察到。有五种DQ-DR单倍型显示与瑞典患者宫颈癌的发生呈正相关。其中两种HLA关联在HPV 18感染患者中具有特异性，这表明致癌性HPV 18比其他高危HPV类型更易引发快速转移肿瘤的能力，可能是由于这些单倍型所携带的HLA分子在抗原呈递方面存在缺陷。
