Radó J P
J Am Geriatr Soc. 1976 Aug;24(8):340-3. doi: 10.1111/j.1532-5415.1976.tb03309.x.
In 2 elderly patients with ascites due to hepatic cirrhosis, potassium excretion decreased during re-administration of potassium-sparing diuretics after recurrence of ascites following withdrawal of previous prolonged treatment. An exaggerated antikaliuretic response and a paradoxic rise in potassium excretion are "unpredictable" changes which may occur during administration of potassium-sparing diuretics at different times in the same patient treated with the same drug.
在2例因肝硬化导致腹水的老年患者中,先前长期治疗停药后腹水复发,再次给予保钾利尿剂期间钾排泄减少。在同一患者使用同一药物治疗的不同时间,给予保钾利尿剂时可能会出现夸张的抗利尿反应和钾排泄反常增加,这些都是“不可预测”的变化。