Mohii El Sayed M, El Mansy Ismail M, Salah Mohamed, Khedr Mohamed Abd Elhamid
J Egypt Soc Parasitol. 2013 Dec;43(3):767-76. doi: 10.12816/0006433.
Ascites is a major complication of liver cirrhosis which carries a poor prognosis. Diuretics are used in treatment of ascites in addition to salt restriction. Monitoring of diuretic response can be achieved by measurement of 24 hours urinary sodium. This study evaluated the accuracy of using spot urinary sodium/potassium ratio as a reliable alternative to 24 hours urinary sodium in assessment of dietary sodium compliance in patients with liver cirrhosis receiving diuretics. Fifty patients presented with liver cirrhosis and ascites were divided into 2 groups: GI 14 (28%) patients diuretic resistant with 24 hours urinary sodium < 78 mEq) and GII 36 (72%) patients diuretic sensitive with 24 hours urinary sodium > 78 mEq. The results showed highly significant correlation between 24 hours urinary sodium and spot urine sodium/potassium ratio with sensitivity 87.5% specificity 56% and accuracy 70% at cutoff point of 1.8.
腹水是肝硬化的主要并发症，预后较差。除限制盐摄入外，利尿剂还用于治疗腹水。通过测量24小时尿钠可监测利尿剂反应。本研究评估了用随机尿钠/钾比值作为24小时尿钠的可靠替代指标，以评估接受利尿剂治疗的肝硬化患者饮食中钠依从性的准确性。50例肝硬化腹水患者分为两组：第一组14例（28%）为利尿剂抵抗患者，24小时尿钠<78 mEq；第二组36例（72%）为利尿剂敏感患者，24小时尿钠>78 mEq。结果显示，24小时尿钠与随机尿钠/钾比值之间存在高度显著相关性，在临界值为1.8时，敏感性为87.5%，特异性为56%，准确性为70%。
