胃癌患者血清中p53自身抗体的检测及其预后相关性。

Detection of p53 autoantibodies in sera of gastric cancer patients and their prognostic relevance.

作者信息

Würl P, Weigmann F, Meye A, Fittkau M, Rose U, Berger D, Rath F W, Dralle H, Taubert H

机构信息

Clinic of General Surgery, Martin Luther University Halle-Wittenberg, Halle/Saale, Germany.

出版信息

Scand J Gastroenterol. 1997 Nov;32(11):1147-51. doi: 10.3109/00365529709002995.

DOI:10.3109/00365529709002995

PMID:9399397

Abstract

BACKGROUND

Changes in the p53 gene product can be immunogenic and enable the formation of p53 serum antibodies (p53ab), detectable in patients with different cancer types. So far, there have been no reports describing the detectability of p53ab in gastric cancer patients.

METHODS

We investigated the presence of p53ab and their clinical relevance in a cohort of 74 gastric cancer patients, using an enzyme-linked immunosorbent assay system.

RESULTS

In our investigation 20.3% of all patients (15 of 74) and 46.9% of the patients with immunohistochemically (IHC) p53-positive tumors (15 of 32) showed detectable p53ab in serum. All p53ab-positive patients had IHC p53-positive tumors. We have found a significant correlation of p53ab with a higher tumor stage (P = 0.002) and also with a poor prognosis of survival (P = 0.04).

CONCLUSION

We have shown that in gastric cancer patients p53ab are also detectable and that p53ab positivity is a predictor of an unfavorable prognosis.

摘要

背景

p53基因产物的变化具有免疫原性，可促使形成p53血清抗体（p53ab），在不同癌症类型的患者中均可检测到。迄今为止，尚无关于胃癌患者中p53ab可检测性的报道。

方法

我们使用酶联免疫吸附测定系统，对74例胃癌患者队列中的p53ab及其临床相关性进行了研究。

结果

在我们的研究中，所有患者中有20.3%（74例中的15例）以及免疫组织化学（IHC）检测p53呈阳性肿瘤的患者中有46.9%（32例中的15例）血清中可检测到p53ab。所有p53ab阳性患者的肿瘤IHC检测p53均呈阳性。我们发现p53ab与较高的肿瘤分期（P = 0.002）以及较差的生存预后（P = 0.04）显著相关。