Tanaka T
Department of Toxicology, Tokyo Metropolitan Research Laboratory of Public Health, Japan.
Toxicol Ind Health. 1997 Nov-Dec;13(6):715-26. doi: 10.1177/074823379701300602.
Chlorpropham was given in the diet to provide levels of 0(control), 0.15, 0.30, and 0.60%, from 5 weeks of age of the F0 generation to 9 weeks of age of the F1 generation in mice, and selected reproductive and neurobehavioral parameters were measured. There were no adverse effects of chlorpropham on either litter size or litter weight and sex ratio at birth. The average body weight of offspring was significantly affected in the low-dose group of each sex and in the high-dose group of females, and was increased in the middle-dose group of males during the lactation period. In neurobehavioral parameters, surface righting at postnatal day (PND) 7 was significantly affected in male offspring in a dose-related manner. Swimming head angle at PND 4 was significantly restrained in male offspring in a dose-related manner, and olfactory orientation at PND 14 was significantly depressed in female offspring in a dose-related manner. The dose levels of chlorpropham in the present study produced some adverse effects in reproductive and neurobehavioral parameters in mice.
在小鼠的饮食中添加氯苯胺灵，从F0代5周龄到F1代9周龄，设置0（对照）、0.15%、0.30%和0.60%的添加水平，并测量选定的生殖和神经行为参数。氯苯胺灵对出生时的窝仔数、窝仔体重和性别比例均无不良影响。在哺乳期，各性别低剂量组和雌性高剂量组的后代平均体重受到显著影响，雄性中剂量组的后代平均体重增加。在神经行为参数方面，出生后第7天（PND 7）雄性后代的表面翻正受到剂量相关的显著影响。出生后第4天（PND 4）雄性后代的游泳头角受到剂量相关的显著抑制，出生后第14天（PND 14）雌性后代的嗅觉定向受到剂量相关的显著抑制。本研究中氯苯胺灵的剂量水平对小鼠的生殖和神经行为参数产生了一些不良影响。
