Pruitt A W, Boles A
J Pediatr. 1976 Aug;89(2):306-9. doi: 10.1016/s0022-3476(76)80475-1.
Twenty-five children with the diagnosis of acute glomerulonephritis were treated with oral or intravenous doses of furosemide. The intravenous administration of 1 mg/kg or greater resulted in an increase in urine volume in all patients. Oral doses of less than 2 mg/kg were not as effective, but there was wide variation in diuretic response to the drug. In 13 patients, plasma concentrations of furosemide were measured. The plasma half-life varied from 2.3 to 4.4 hours after intravenous administration of the drug. The plasma concentration of furosemide did not correlate with diuretic response.
25名诊断为急性肾小球肾炎的儿童接受了口服或静脉注射速尿治疗。静脉注射1mg/kg或更高剂量可使所有患者尿量增加。口服剂量低于2mg/kg效果不佳，但药物利尿反应差异很大。对13名患者测量了速尿的血浆浓度。静脉注射该药物后，血浆半衰期在2.3至4.4小时之间。速尿的血浆浓度与利尿反应无关。
