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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Curtis D R, Game C J, Lodge D, McCulloch R M

J Physiol. 1976 Jun;258(1):227-42. doi: 10.1113/jphysiol.1976.sp011416.

In cats anaesthetized with pentobarbitone a pharmacological investigation was made of the inhibition of Renshaw cells by dorsal root afferent volleys and ventral root antidromic volleys, and of the inhibition of motoneurones by Renshaw cells. 2. The effects of strychnine, bicuculline and tetanus toxin indicate that both glycine and GABA operate as inhibitory transmitters released on Renshaw cells by dorsal root volleys. 3. The 'mutual' inhibition of Renshaw cells, and the recurrent inhibition of motoneurones by Renshaw cells, are suppressed by strychnine: Renshaw cells are thus glycinergic inhibitory neurones, a proposal consistant with recent evidence for strychnine-sensitive inhibition of Ia interneurones by Renshaw cells. 4. The 'pause' which follows high frequency synaptic excitation of Renshaw cells is insensitive to strychnine, bicuculline and tetanus toxin, and is considered unlikely to be the consequence of synaptic inhibition.

在戊巴比妥麻醉的猫身上，对背根传入冲动和腹根逆向冲动对闰绍细胞的抑制作用，以及闰绍细胞对运动神经元的抑制作用进行了药理学研究。2. 士的宁、荷包牡丹碱和破伤风毒素的作用表明，甘氨酸和γ-氨基丁酸均作为背根冲动释放到闰绍细胞上的抑制性递质起作用。3. 闰绍细胞的“相互”抑制作用以及闰绍细胞对运动神经元的回返抑制作用，被士的宁抑制：因此，闰绍细胞是甘氨酸能抑制性神经元，这一观点与最近关于闰绍细胞对Ia中间神经元进行士的宁敏感抑制的证据一致。4. 闰绍细胞高频突触兴奋后出现的“暂停”对士的宁、荷包牡丹碱和破伤风毒素不敏感，并且被认为不太可能是突触抑制的结果。

Curtis D R, Game C J, Lodge D, McCulloch R M

J Physiol. 1976 Jun;258(1):227-42. doi: 10.1113/jphysiol.1976.sp011416.

In cats anaesthetized with pentobarbitone a pharmacological investigation was made of the inhibition of Renshaw cells by dorsal root afferent volleys and ventral root antidromic volleys, and of the inhibition of motoneurones by Renshaw cells. 2. The effects of strychnine, bicuculline and tetanus toxin indicate that both glycine and GABA operate as inhibitory transmitters released on Renshaw cells by dorsal root volleys. 3. The 'mutual' inhibition of Renshaw cells, and the recurrent inhibition of motoneurones by Renshaw cells, are suppressed by strychnine: Renshaw cells are thus glycinergic inhibitory neurones, a proposal consistant with recent evidence for strychnine-sensitive inhibition of Ia interneurones by Renshaw cells. 4. The 'pause' which follows high frequency synaptic excitation of Renshaw cells is insensitive to strychnine, bicuculline and tetanus toxin, and is considered unlikely to be the consequence of synaptic inhibition.

在戊巴比妥麻醉的猫身上，对背根传入冲动和腹根逆向冲动对闰绍细胞的抑制作用，以及闰绍细胞对运动神经元的抑制作用进行了药理学研究。2. 士的宁、荷包牡丹碱和破伤风毒素的作用表明，甘氨酸和γ-氨基丁酸均作为背根冲动释放到闰绍细胞上的抑制性递质起作用。3. 闰绍细胞的“相互”抑制作用以及闰绍细胞对运动神经元的回返抑制作用，被士的宁抑制：因此，闰绍细胞是甘氨酸能抑制性神经元，这一观点与最近关于闰绍细胞对Ia中间神经元进行士的宁敏感抑制的证据一致。4. 闰绍细胞高频突触兴奋后出现的“暂停”对士的宁、荷包牡丹碱和破伤风毒素不敏感，并且被认为不太可能是突触抑制的结果。