BRCA2基因杂合性缺失在人类乳腺癌中的预后价值。
Prognostic value of loss of heterozygosity at BRCA2 in human breast carcinoma.
作者信息
Bièche I, Noguès C, Rivoilan S, Khodja A, Latil A, Lidereau R
机构信息
Laboratoire d'Oncogénétique, Centre René Huguenin, St-Cloud, France.
出版信息
Br J Cancer. 1997;76(11):1416-8. doi: 10.1038/bjc.1997.572.
Abstract
To confirm several recent studies pointing to loss of heterozygosity (LOH) at BRCA2 as a prognostic factor in sporadic breast cancer, we examined this genetic alteration in a large series of human primary breast tumours for which long-term patient outcomes were known. LOH at BRCA2 correlated only with low oestrogen and progesterone receptor content. Univariate analysis of metastasis-free survival and overall survival (log-rank test) showed no link with BRCA2 status (P = 0.34, P = 0.29 respectively). LOH at BRCA2 does not therefore appear to be a major prognostic marker in sporadic breast cancer.
摘要
为了证实最近几项研究指出的，BRCA2基因杂合性缺失（LOH）是散发性乳腺癌的一个预后因素，我们在一系列已知患者长期预后情况的人类原发性乳腺肿瘤中检测了这种基因改变。BRCA2基因的杂合性缺失仅与低雌激素和孕激素受体含量相关。对无转移生存期和总生存期进行单因素分析（对数秩检验）显示，其与BRCA2状态无关（分别为P = 0.34，P = 0.29）。因此，BRCA2基因的杂合性缺失似乎不是散发性乳腺癌的主要预后标志物。
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