Woltersdorf O W, Robb C M, Bicking J B, Watson L S, Cragoe E J
J Med Chem. 1976 Jul;19(7):972-5. doi: 10.1021/jm00229a024.
A variety of [(2-substituted and 2,2-disubstituted vinyl)aryloxy]acetic acids was synthesized in which the substituents were primarily electron-withdrawing groups. These compounds were tested in dogs for their saluretic and diuretic properties. Many of the compounds exhibited significant activity; however, they were generally less potent than those reported in the three earlier papers in this series.
