激肽释放酶对肾素的激活：血浆肾素碱性激活的证据。

Renin-activation by kallikrein: evidence for alkaline-activation of plasma renin.

作者信息

Hummerich W, Feltkamp H, Konrads A, Ahlmann P, Bornhofen H

出版信息

Eur J Clin Invest. 1979 Dec;9(6):447-9. doi: 10.1111/j.1365-2362.1979.tb00911.x.

DOI:10.1111/j.1365-2362.1979.tb00911.x

Abstract

Porcine pancreatic kallikrein leads to a significant activation of human plasma renin when incubated at pH 8.2. 'Endogenous' activation of plasma renin can be seen by incubation of plasmas at the same pH. Both 'endogenous' alkaline- and kallikrein-activation of plasma renin can be inhibited by aprotinin. Both, kallikrein- and 'endogenous' alkaline activation of plasma renin are significantly correlated to cryo- and acid-activation. We suggest that kallikrein-and 'endogenous' alkaline-activiation come close to the in vivo activation process.

摘要

猪胰激肽释放酶在pH 8.2孵育时可导致人血浆肾素显著激活。通过在相同pH下孵育血浆可观察到血浆肾素的“内源性”激活。血浆肾素的“内源性”碱性激活和激肽释放酶激活均可被抑肽酶抑制。血浆肾素的激肽释放酶激活和“内源性”碱性激活均与冷冻激活和酸激活显著相关。我们认为，激肽释放酶激活和“内源性”碱性激活接近体内激活过程。