Sulkowska M, Sulkowski S, Terlikowski S, Nowak H F
Department of Pathological Anatomy, Medical Academy, Białystok.
Pol J Pathol. 1997;48(3):179-88.
The effect of repeated doses of TNF-alpha on the histological picture of the pulmonary tissue was analyzed in the present study. Special attention was paid to the lung rebuilding processes. TNF-alpha was applied intraperitoneally for two weeks in a dose of 10 micrograms/0.5 ml PBS/24h. Morphological analysis of the pulmonary tissue was performed after 1 and 28 days following the last TNF-alpha dose. The study revealed focal pulmonary tissue rebuilding with emphysema-like changes twenty eight days following termination of TNF-alpha administration. The rebuilding processes included interalveolar septal atrophy, collagen accumulation and damage-repair changes in type II alveolar epithelial cells. It has been demonstrated that apart from the protease-antiprotease hypothesis of the lung emphysema, the inflammatory-repair hypothesis should be considered. Both hypotheses are complementary to each other and interpret the emphysema-like changes as complications of various pathological conditions of the pulmonary tissue.
本研究分析了重复剂量的肿瘤坏死因子-α（TNF-α）对肺组织组织学图像的影响。特别关注了肺重建过程。TNF-α以10微克/0.5毫升磷酸盐缓冲液/24小时的剂量腹腔注射两周。在最后一次注射TNF-α后的1天和28天对肺组织进行形态学分析。研究发现，在TNF-α给药终止28天后，肺组织出现局灶性重建，并伴有类肺气肿样改变。重建过程包括肺泡间隔萎缩、胶原蛋白积累以及II型肺泡上皮细胞的损伤修复变化。已经证明，除了肺气肿的蛋白酶-抗蛋白酶假说外，还应考虑炎症-修复假说。这两种假说相互补充，将类肺气肿样改变解释为肺组织各种病理状况的并发症。
