Eiholzer U, Weber R, Stutz K, Steinert H
Centre for Adolescent Medicine, Zurich, Switzerland.
Acta Paediatr Suppl. 1997 Nov;423:66-8. doi: 10.1111/j.1651-2227.1997.tb18374.x.
Nine prepubertal children with Prader-Willi syndrome were treated with growth hormone (GH; 24 IU/m2/week) for 6 months. Mean height increased by 0.8 SD and mean weight for height decreased by 0.7 SD over this 6-month treatment period. Body fat, measured by dual-energy X-ray absorptiometry, decreased by 22.5% over the period of GH treatment, whereas fat-free mass increased by 14%. These preliminary results indicate that GH is effective in increasing height and normalizing body composition in patients with Prader-Willi syndrome.
九名青春期前普拉德-威利综合征患儿接受了生长激素（GH；24国际单位/平方米/周）治疗6个月。在这6个月的治疗期内，平均身高增加了0.8标准差，身高对应的平均体重下降了0.7标准差。通过双能X线吸收法测量的体脂在生长激素治疗期间下降了22.5%，而去脂体重增加了14%。这些初步结果表明，生长激素对增加普拉德-威利综合征患者的身高和使身体成分正常化有效。
