寻找治疗美洲锥虫病的药物：在小鼠模型中对一些“标准”进行评估。
In pursuit of drugs for American trypanosomiasis: evaluation of some "standards" in a mouse model.
作者信息
Kinnamon K E, Poon B T, Hanson W L, Waits V B
机构信息
Division of Experimental Therapeutics, Walter Reed Army Institute of Research, Washington, District of Columbia 20307-5100, USA.
出版信息
Proc Soc Exp Biol Med. 1997 Dec;216(3):424-8. doi: 10.3181/00379727-216-44192.
Forty-nine "standard" compounds known to be useful in the treatment of other diseases were tested for their suppressive activity against the trypomastigotes of Trypanosoma cruzi-infected mice. The most active was the antidepressant protriptyline, which was almost three times as effective as the reference drug, nifurtimox. A major value of the present data is to demonstrate the refractoriness of the T. cruzi parasite against many of the drug standards that have known biological activity.
对49种已知可用于治疗其他疾病的“标准”化合物进行了测试，以检测它们对感染克氏锥虫的小鼠的锥鞭毛体的抑制活性。最有效的是抗抑郁药普罗替林，其效果几乎是参比药物硝呋替莫的三倍。本数据的一个主要价值在于证明克氏锥虫寄生虫对许多具有已知生物活性的药物标准具有耐药性。
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