人类和小鼠TEP1基因的比较基因图谱，该基因编码端粒酶的一种蛋白质成分。

Comparative gene mapping of the human and mouse TEP1 genes, which encode one protein component of telomerases.

作者信息

Saito T, Matsuda Y, Suzuki T, Hayashi A, Yuan X, Saito M, Nakayama J, Hori T, Ishikawa F

机构信息

Genome Research Group, National Institute of Radiological Sciences, Chiba, Japan.

出版信息

Genomics. 1997 Nov 15;46(1):46-50. doi: 10.1006/geno.1997.5005.

DOI:10.1006/geno.1997.5005

PMID:9403057

Abstract

The chromosomal locations of the human TEP1 (telomerase protein component 1) and mouse Tep1 genes, which were originally named TLP1 (telomerase protein 1) or TP1 (telomerase-associated protein 1), were determined by direct R-banding FISH and a molecular linkage analysis with interspecific backcross mice. The human TEP1 and mouse Tep1 genes were mapped by FISH to human chromosome 14q11.2 and to the C2D1 band of mouse chromosome 14, respectively. By means of genetic linkage mapping, the mouse gene was further localized as being 2.7 cM distal to D14Mit18 and D14Mit134 and 2.0 cM proximal to D14Mit5 on mouse chromosome 14, where conserved linkage homology with human chromosome 14q11-q12 has been identified.

摘要

人类TEP1（端粒酶蛋白成分1）和小鼠Tep1基因最初分别命名为TLP1（端粒酶蛋白1）或TP1（端粒酶相关蛋白1），其染色体定位通过直接R带荧光原位杂交（FISH）以及与种间回交小鼠的分子连锁分析来确定。通过FISH将人类TEP1基因和小鼠Tep1基因分别定位到人类染色体14q11.2和小鼠染色体14的C2D1带。通过遗传连锁图谱分析，小鼠基因进一步定位在小鼠染色体14上D14Mit18和D14Mit134远端2.7 cM处以及D14Mit5近端2.0 cM处，在该区域已确定与人类染色体14q11 - q12存在保守的连锁同源性。