Rahn R, Adamietz I A, Boettcher H D, Schaefer V, Reimer K, Fleischer W
Department of Dentistry, Klinikum der J.W.-Goethe-Universität, Frankfurt/Main, Germany.
Dermatology. 1997;195 Suppl 2:57-61. doi: 10.1159/000246032.
In an open study, the efficacy of povidone-iodine in the prophylaxis of mucositis during antineoplastic radiochemotherapy was determined. 40 patients were randomly assigned to a treatment or control group (each 20 patients). All patients received standard prophylaxis of mucositis with nystatin, dexpanthenol, rutoside and immunoglobulin. In addition, the patients of the treatment group performed 4 times daily rinsing with povidone-iodine, the control patients with sterile water. Clinical examination of the oral mucosa was performed weekly during the radiation period and up to 6 weeks after the end of therapy. Oral mucositis was observed in 14 patients of the treatment group (mean grading: 1.0) and in all 20 patients of the control group (mean grading: 3.0). The mean onset of mucositis was after 2.25 weeks in treatment patients and 1.5 weeks in control patients. The mean total duration of mucositis was 2.75 weeks in treatment patients and 9.25 weeks in control patients. The mean AUC values were 2.5 in treatment patients and 15.75 in control patients. All findings were statistically significantly different between the two groups. It is concluded that rinsing with povidone-iodine reduces the incidence, severity and duration of oral mucositis during antineoplastic radiochemotherapy.
在一项开放性研究中，确定了聚维酮碘在抗肿瘤放化疗期间预防口腔黏膜炎的疗效。40例患者被随机分为治疗组或对照组（每组20例患者）。所有患者均接受制霉菌素、泛醇、芦丁和免疫球蛋白对口腔黏膜炎的标准预防措施。此外，治疗组患者每天用聚维酮碘漱口4次，对照组患者用无菌水漱口。在放疗期间每周进行一次口腔黏膜的临床检查，并在治疗结束后长达6周内持续检查。治疗组14例患者出现口腔黏膜炎（平均分级：1.0），对照组所有20例患者均出现口腔黏膜炎（平均分级：3.0）。治疗组患者口腔黏膜炎的平均发病时间为2.25周，对照组患者为1.5周。治疗组患者口腔黏膜炎的平均总持续时间为2.75周，对照组患者为9.25周。治疗组患者的平均AUC值为2.5，对照组患者为15.75。两组之间所有结果在统计学上均有显著差异。得出的结论是，在抗肿瘤放化疗期间，用聚维酮碘漱口可降低口腔黏膜炎的发生率、严重程度和持续时间。
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