Nakayama J, Suzuki A
Department of Applied Biological Chemistry, University of Tokyo, Japan.
Biosci Biotechnol Biochem. 1997 Nov;61(11):1796-9. doi: 10.1271/bbb.61.1796.
Certain plasmids in Enterococcus faecalis encode a mating response to recipient-produced peptide sex pheromones. Targeted disruption of tra genes on pPD1 suggested that TraA plays a central role in the plasmid-specific pheromone signaling pathway. TraA functioned as a negative regulator for the pheromone-inducible conjugal transfer. Complementation analysis of pPD1 tra gene mutants by pAD1 suggested that the pheromone binding function of TraC was non-specific between these plasmids, but the function of TraA and the pheromone shutdown function of TraB are plasmid-specific.
粪肠球菌中的某些质粒编码对受体产生的肽性信息素的交配反应。对pPD1上tra基因的靶向破坏表明，TraA在质粒特异性信息素信号通路中起核心作用。TraA作为信息素诱导的接合转移的负调节因子。pAD1对pPD1 tra基因突变体的互补分析表明，TraC的信息素结合功能在这些质粒之间是非特异性的，但TraA的功能和TraB的信息素关闭功能是质粒特异性的。
