Flandrin G
Hôpital Necker, Paris, France.
Pathol Biol (Paris). 1997 Sep;45(7):545-9.
A discussion is provided of the cytologic abnormalities in myelodysplastic syndromes (MDS), which remain central to the diagnosis and classification of these conditions. Accurate identification of the blast cells is essential since the proportion of these cells is of considerable prognostic significance. A description is given of the FAB classification scheme, which is both simple and reproducible. Prognostic scoring systems based on bone marrow blast proportion, cytopenias, and karyotypic abnormalities are also discussed.
本文讨论了骨髓增生异常综合征(MDS)中的细胞异常情况,这些异常对于这些病症的诊断和分类仍然至关重要。准确识别原始细胞至关重要,因为这些细胞的比例具有相当大的预后意义。本文介绍了FAB分类方案,该方案既简单又具有可重复性。还讨论了基于骨髓原始细胞比例、血细胞减少和核型异常的预后评分系统。