Oscier D
Royal Bournemouth Hospital, Department of Haematology, UK.
Pathol Biol (Paris). 1997 Sep;45(7):587-93.
An ideal classification of the chronic myeloid leukemias would be based on a thorough understanding of the aetiology, pathogenesis, clinical and laboratory features, and natural history of the various conditions which comprise CML. Only in the case of CGL is the pathogenesis well understood and the diagnosis of the remaining disorders is still largely based on clinical and morphological criteria. It is inevitable for the reasons previously discussed that there will be cases which either defy classification or fall within the diagnostic criteria of more than one disorder. As long as careful clinical and morphological observation continues in parallel with advances in cellular and molecular biology it seems inevitable that the current debate about the inter-relationship between CMML, aCML and Philadelphia negative CGL will be resolved.
慢性髓系白血病的理想分类应基于对构成慢性粒细胞白血病（CML）的各种病症的病因、发病机制、临床和实验室特征以及自然史的透彻理解。只有慢性粒细胞白血病（CGL）的发病机制得到了很好的理解，而其余病症的诊断仍主要基于临床和形态学标准。基于先前讨论的原因，不可避免地会出现一些病例，它们要么难以分类，要么符合一种以上病症的诊断标准。只要在细胞和分子生物学取得进展的同时继续进行仔细的临床和形态学观察，目前关于慢性粒-单核细胞白血病（CMML）、不典型慢性粒细胞白血病（aCML）和Ph阴性慢性粒细胞白血病（CGL）之间相互关系的争论似乎必然会得到解决。
