Chen M D, Lin P Y, Sheu W H
Division of Endocrinology and Metabolism, Taichung Veterans General Hospital, Taiwan, ROC.
Biol Trace Elem Res. 1997 Oct-Nov;60(1-2):123-9. doi: 10.1007/BF02783315.
To know whether plasma zinc status is altered under acute hyperglycemic state, the interrelationships among plasma glucose, insulin, and zinc concentrations during oral glucose tolerance test (OGTT) in obese individuals and their lean controls were studied. Plasma glucose and insulin concentrations under fasting as well as those values in response to OGTT were significantly higher in obese individuals than those in lean controls. On the other hand, the obese had lower fasting plasma zinc concentrations compared to lean controls (13.5 vs 18.1 mumol/L, p < 0.005). Under fasting, plasma zinc concentrations in overall individuals inversely correlated to their body mass index (BMI) (r = -0.516), plasma glucose (r = -0.620), and plasma insulin (r = -0.510). However, there were no significant changes in plasma zinc and copper values during OGTT in both obese individuals and lean controls. This study showed that plasma zinc values had no changes during OGTT in obese individuals. The results also indicated that lower fasting plasma zinc concentrations in obese individuals were not the short-term metabolic result.
为了解急性高血糖状态下血浆锌水平是否改变，研究了肥胖个体及其体重正常的对照者在口服葡萄糖耐量试验（OGTT）期间血浆葡萄糖、胰岛素和锌浓度之间的相互关系。肥胖个体空腹时的血浆葡萄糖和胰岛素浓度以及对OGTT的反应值均显著高于体重正常的对照者。另一方面，肥胖者空腹血浆锌浓度低于体重正常的对照者（13.5对18.1μmol/L，p<0.005）。空腹时，总体人群的血浆锌浓度与其体重指数（BMI）（r=-0.516）、血浆葡萄糖（r=-0.620）和血浆胰岛素（r=-0.510）呈负相关。然而，肥胖个体和体重正常的对照者在OGTT期间血浆锌和铜值均无显著变化。本研究表明，肥胖个体在OGTT期间血浆锌值无变化。结果还表明，肥胖个体空腹血浆锌浓度较低并非短期代谢结果。
