Hiramatsu M, Hyodo T, Kameyama T
Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Meijo University, Nagoya, Japan.
Neurosci Lett. 1997 Oct 24;236(1):45-8. doi: 10.1016/s0304-3940(97)00757-x.
We investigated whether carbachol, a muscarinic receptor agonist, induces learning and memory impairments, and U-50,488H, a selective kappa opioid receptor agonist, ameliorates the impairments of learning and memory using a step-down type passive avoidance task in mice. Carbachol induced a dose-related dual response. Carbachol (3 nmol/mouse, i.c.v.) significantly shortened the step-down latency, while lower (1 nmol) and higher (10 nmol) doses of carbachol did not induce learning and memory impairments. U-50,488H (0.64 micromol/kg, s.c.) significantly improved carbachol-induced impairments of learning and memory. These findings suggest that kappa opioid receptor agonists ameliorate learning and memory impairments which may associate with dysfunction of presynaptic cholinergic neurons.
我们使用小鼠的一步跳下式被动回避任务，研究了毒蕈碱受体激动剂卡巴胆碱是否会诱导学习和记忆障碍，以及选择性κ阿片受体激动剂U-50,488H是否能改善学习和记忆障碍。卡巴胆碱诱导了剂量相关的双重反应。卡巴胆碱（3 nmol/小鼠，脑室内注射）显著缩短了跳下潜伏期，而较低剂量（1 nmol）和较高剂量（10 nmol）的卡巴胆碱并未诱导学习和记忆障碍。U-50,488H（0.64 μmol/kg，皮下注射）显著改善了卡巴胆碱诱导的学习和记忆障碍。这些发现表明，κ阿片受体激动剂可改善可能与突触前胆碱能神经元功能障碍相关的学习和记忆障碍。
