Suppr超能文献

哮喘儿童在北海气候地区停留期间减少长期类固醇治疗的可能性(作者译)

[Possibilities for a reduction of long-term steroid treatment in asthmatic children during a stay in northsea climate (author's transl)].

作者信息

Schütze G

出版信息

Monatsschr Kinderheilkd (1902). 1976 Jul;124(7):557-62.

PMID:940564
Abstract
  1. 40 children with Asthma bronchiale under long-term Cortisone therapy were admitted as in-patients of a clinic in the climate of the Northsea. 37 children needed Cortisone therapy because of serious attacks of Asthma bronchiale, and 3 children because of disturbing neurodermitis constitutionalis. -- 2. Corticoids were discontinued abruptly, immediately after admission. a) In 34 children the discontinuation had no adverse effect the following 6 to 8 weeks, or even longer, there was no need for Cortisone therapy. b) In 4 children during the first 2 weeks and in 2 further children during the 5th or 6th week, the asthmatic disorder deteriorated to such a degree that Cortisone therapy had to be re-introduced. -- 3. On the base of the reported observation, it is concluded that under the conditions of the Northsea climate it is of advantage for children with Asthma bronchiale and Neurodermitis to discontinue abruptly Cortisone therapy because a) this type of therapy which involves the potential risk of unwanted side effects can be shortened and b) the specific positive effect of climatic changes during the first couple of weeks is utilized to a greater extent. The gradual reduction of steroid therapy would diminish this particular stimulation. However, this kind of treatment requires close clinical observation to anticipate an acute "Addison-Crises". -- 4. All children with serious dispuce already during the first days of their stay in the clinic clearly need continuation of steroid therapy. -- Otherwise, even previous steroid therapy for more than one year is no contradiction for the recommended procedure as long as the clinical condition of the patient allows for it.
摘要
  1. 40名长期接受可的松治疗的支气管哮喘儿童作为住院患者入住北海地区气候条件下的一家诊所。37名儿童因严重支气管哮喘发作需要可的松治疗,3名儿童因严重的特应性皮炎需要治疗。——2. 入院后立即突然停用皮质类固醇。a) 34名儿童在接下来的6至8周甚至更长时间内停用后没有不良反应,无需进行可的松治疗。b) 4名儿童在最初2周内,另外2名儿童在第5或6周时,哮喘病情恶化到不得不重新引入可的松治疗的程度。——3. 根据所报告的观察结果得出结论,在北海气候条件下,对于支气管哮喘和特应性皮炎儿童,突然停用可的松治疗是有利的,因为a) 这种存在不良副作用潜在风险的治疗方法可以缩短,b) 最初几周气候变化的特定积极作用能得到更大程度的利用。逐渐减少类固醇治疗会减少这种特殊刺激。然而,这种治疗需要密切的临床观察以预见急性“艾迪生病危象”。——4. 所有在诊所住院头几天就有严重病情的儿童显然需要继续进行类固醇治疗。——否则,只要患者的临床状况允许,即使之前接受过一年以上的类固醇治疗也与推荐的程序不矛盾。

文献AI研究员

20分钟写一篇综述,助力文献阅读效率提升50倍。

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

文档翻译

学术文献翻译模型,支持多种主流文档格式。

立即体验