肾小管坏死在急性肾衰竭病理生理学中的作用。

The role of tubular necrosis in the pathophysiology of acute renal failure.

作者信息

Hsu C H, Kurtz T W, Weller J M

出版信息

Nephron. 1976;17(3):204-14. doi: 10.1159/000180724.

Abstract

Renal tubular function was evaluated in vitro by kidney slice uptakes of p-aminohippurate (PAH) and tetraethylammonium (TEA) at 24 and 48 h in water-drinking rats and at 24 h in chronic saline-loaded rats after induction of acute tubular necrosis (ATN) by HgCl2 and glycerol injection. Significant correlations between decrease tubular uptake of PAH and TEA and elevated serum creatinine levels were noted in both models of ATN in water- and saline-drinking rats. However, with the same degree of impairment of PAH and TEA uptakes the creatinine was significantly lower in saline-loaded rats than in water-drinking rats in both forms of ATN. The correlation between impaired tubular function and elevated creatinine suggests that tubular damage and glomerular filtration reduction might be pathophysiologically related in ATN.

摘要

通过在饮水大鼠中于24小时和48小时以及在慢性盐水负荷大鼠中于注射氯化汞和甘油诱导急性肾小管坏死（ATN）后24小时，采用肾切片摄取对氨基马尿酸（PAH）和四乙铵（TEA）的方法，在体外评估肾小管功能。在饮水和盐水负荷大鼠的两种ATN模型中，均观察到PAH和TEA肾小管摄取减少与血清肌酐水平升高之间存在显著相关性。然而，在两种形式的ATN中，对于相同程度的PAH和TEA摄取受损，盐水负荷大鼠的肌酐水平显著低于饮水大鼠。肾小管功能受损与肌酐升高之间的相关性表明，在ATN中肾小管损伤和肾小球滤过减少可能在病理生理上相关。