Yamadera H, Kato M, Tsukahara Y, Brandeis D, Okuma T
Department of Neuropsychiatry, Nippon Medical School, Tokyo, Japan.
Acta Neurobiol Exp (Wars). 1997;57(2):151-5. doi: 10.55782/ane-1997-1221.
EEG effects of zopiclone (7.5 mg), a cyclopyrrolone derivative with hypnotic action, were compared with effects of diazepam (10 mg). Multichannel EEG recordings, double-blind crossover trials with placebo, and oral single doses were used in healthy volunteers. Vigilance-controlled EEG before and after zopiclone (and placebo), and before and after diazepam (and placebo) were analyzed into FFT power spectra. Effects were assessed as placebo-referred pre-post-medication power differences in four frequency bands. Overall statistics showed significant (P < 0.007) global differences between medication effects in the delta frequency band (0.5-3.5 Hz). After zopiclone, fronto-central delta increased bilaterally, whereas after diazepam delta decreased over centro-parietal to right temporo-occipital regions. These spatially different brain electric effects show that different neuronal populations must have become active in response to zopiclone and diazepam.
将具有催眠作用的环吡咯酮衍生物佐匹克隆（7.5毫克）的脑电图效应与地西泮（10毫克）的效应进行了比较。在健康志愿者中使用多通道脑电图记录、安慰剂双盲交叉试验和口服单剂量药物。对佐匹克隆（和安慰剂）前后以及地西泮（和安慰剂）前后的警觉性控制脑电图进行快速傅里叶变换（FFT）功率谱分析。效应评估为四个频段内药物治疗前后相对于安慰剂的功率差异。总体统计显示，在δ频段（0.5 - 3.5赫兹），药物效应之间存在显著（P < 0.007）的总体差异。服用佐匹克隆后，额中央δ波双侧增加，而服用地西泮后，δ波在中央顶叶至右颞枕叶区域减少。这些在空间上不同的脑电效应表明，不同的神经元群体在对佐匹克隆和地西泮的反应中一定变得活跃起来。
