Fukamauchi F, Wang Y J, Mataga N, Kusakabe M
Department of Molecular Medical Science, Medical Research Institute, Tokyo Medical and Dental University, Japan.
Eur J Pharmacol. 1997 Oct 29;338(1):7-10. doi: 10.1016/s0014-2999(97)01298-3.
Tenascin is a large extracellular matrix glycoprotein which is highly expressed in the developing nervous system. To examine the role of tenascin in vivo, we have produced mice in which the tenascin-gene is inactivated. These animals did not easily habituate to unfamiliar circumstances and displayed hyperlocomotion. A dopamine receptor agonist, apomorphine, reduced this hyperlocomotion dose dependently, but this phenomenon was not due to the appearance of apomorphine-induced stereotypic behavior, suggesting that tenascin-gene mutant mice have a paradoxical behavioral response to apomorphine compared to wild-type mice.
腱生蛋白是一种大型细胞外基质糖蛋白，在发育中的神经系统中高度表达。为了研究腱生蛋白在体内的作用，我们培育出了腱生蛋白基因失活的小鼠。这些动物不容易适应陌生环境，并且表现出运动亢进。多巴胺受体激动剂阿扑吗啡可剂量依赖性地减少这种运动亢进，但这种现象并非由阿扑吗啡诱导的刻板行为所致，这表明与野生型小鼠相比，腱生蛋白基因敲除小鼠对阿扑吗啡有矛盾的行为反应。
