Jacobsson L, von Knorring L
Psychiatr Neurol Med Psychol (Leipz). 1976 Feb;28(2):114-9.
In an open study 17 patients with depressive disorders, 5 patients with unipolar affec. Only 9 patients completed the trial. The frequency of side-effects, especially nausea and vomiting was high, which will probably limit the clinical use of the drug. Of the sion NUD, were treated with a new potential antidepressant, ICI 58.834 (Vivalan). tive psychosis, 9 patients with reactio-neurotico-depressiva and 3 patients with deprespatients who completed the trial 1 was recovered and 4 were improved. Thus the antidepressive effect is dubious and must be tested in controlled studies.
在一项开放性研究中，17名抑郁症患者、5名单相情感障碍患者、9名反应性神经症抑郁症患者和3名抑郁性精神病患者接受了一种新的潜在抗抑郁药ICI 58.834（维瓦兰）的治疗。只有9名患者完成了试验。副作用的发生率很高，尤其是恶心和呕吐，这可能会限制该药物的临床应用。在完成试验的患者中，1名康复，4名病情好转。因此，其抗抑郁效果值得怀疑，必须在对照研究中进行检验。
