Walsh C H, Soler N G, James H, Harvey T C, Thomas B J, Fremlin J H, Fitzgerald M G, Malins J M
Q J Med. 1976 Apr;45(178):295-301.
Serial measurements of whole body potassium and whole body nitrogen were carried out in 18 newly diagnosed diabetcs. Initial measurements were made before treatment of diabetes was commenced, and further measurements were carried out following the start of treatment. Six patients required insulin and the remainder were treated either with diet alone (four cases) or with diet and oral hypoglycaemic agents. Significant increases in whole body potassium and whole body nitrogen were noted following control of diabetes.Thesees. These changes were most marked in the patients treated with insulin. The techniques used for measurement of body potassium and nitrogen offer considerable advantages over conventional metabolic balance studies and the results indicate that the losses of potassium and nitrogen during period of poor diabetic control are much greater than that has been realized.
对18名新诊断的糖尿病患者进行了全身钾和全身氮的系列测量。初始测量在糖尿病治疗开始前进行，治疗开始后进行了进一步测量。6名患者需要胰岛素治疗，其余患者要么仅接受饮食治疗（4例），要么接受饮食和口服降糖药治疗。糖尿病得到控制后，全身钾和全身氮显著增加。这些变化在接受胰岛素治疗的患者中最为明显。用于测量身体钾和氮的技术比传统的代谢平衡研究具有相当大的优势，结果表明，糖尿病控制不佳期间钾和氮的损失比之前认识到的要大得多。
