Erwin D T
South Med J. 1976 Jul;69(7):935-7.
The stone-forming process includes crystal formation, crystal aggregation, and retention time to allow growth. The crystal-forming process, in turn, is influenced by the pH of the urine, the solute load, and inhibitors of crystallization. Idiopathic stone disease is characterized by recurrent formation of calcium oxalate, calcium phosphate, and hydroxyapatite stones without an apparent underlying cause. Treatment of idiopathic stone disease has been aimed at decreasing the solute concentration, increasing the solubility of calcium phosphate, or interfering with extension of the crystal lattice.
结石形成过程包括晶体形成、晶体聚集以及允许生长的保留时间。反过来，晶体形成过程又受尿液pH值、溶质负荷和结晶抑制剂的影响。特发性结石病的特征是反复形成草酸钙、磷酸钙和羟基磷灰石结石，且无明显潜在病因。特发性结石病的治疗旨在降低溶质浓度、增加磷酸钙的溶解度或干扰晶格的扩展。
