Stobernack A, Achatzy R, Engelmann C
Abteilung für Thorax- und Gefässchirurgie, Lungenklinik Hemer.
Chirurg. 1997 Sep;68(9):921-7; discussion 928. doi: 10.1007/s001040050296.
The epidemic spread of tuberculosis after World War II and the deficiency of appropriate antituberculotic drugs led to a renaissance of surgical procedure such as plombage thoracoplasty, initiated in 1891 by Tuffier. Especially in Germany the insertion of paraffin and polyethylene was used in order to achieve an extrapleural pneumothorax in order to collapse the tuberculous cavities in the upper lobes. Due to a high rate of early complications and the assumed cancerogenicity, in a considerable number of cases the material was removed soon after its deployment. In some cases with the filling remaining in place, 30-40 years later infections and/or neoplasms occurred. From 1985 to 1996 in two centers of thoracic surgery 13 patients underwent procedures for removal of filling material. The patients suffered from infections (n = 11), malignant lymphoma associated with infection of the plombage (n = 1) and bronchial carcinoma (n = 1). Technically, we performed the thoracoplasty described by Schede (n = 9). Schede's thoracoplasty in combination with a muscle flap repair (n = 1) or partial resection of the thoracic wall (n = 1), an empyemectomy (n = 1), and an en-bloc pleuropneumonectomy (n = 1). All patients suffered from multiple underlying diseases (COPD, coronary heart disease, diabetes mellitus). However, apart from beside two procedure related deaths (pulmonary embolism n = 1, pneumonia complicated by multi-organ failure n = 1) no other major complications were observed. The plombage material in the case of malignant lymphoma is probably carcinogenic in relation to the time of exposure and should be removed in all cases.
第二次世界大战后结核病的流行以及合适抗结核药物的短缺,导致了诸如胸廓成形术等外科手术的复兴,该手术由图菲耶于1891年首创。尤其是在德国,为了实现胸膜外气胸以使上叶的结核空洞塌陷,采用了石蜡和聚乙烯植入术。由于早期并发症发生率高以及假定的致癌性,在相当多的病例中,材料在植入后不久就被取出。在一些填充物保留原位的病例中,30至40年后出现了感染和/或肿瘤。1985年至1996年,在两个胸外科中心,13名患者接受了取出填充物的手术。这些患者患有感染(n = 11)、与填充感染相关的恶性淋巴瘤(n = 1)和支气管癌(n = 1)。从技术上讲,我们进行了谢德描述的胸廓成形术(n = 9)。谢德胸廓成形术联合肌瓣修复(n = 1)或胸壁部分切除术(n = 1)、脓胸切除术(n = 1)和整块胸膜肺切除术(n = 1)。所有患者都患有多种基础疾病(慢性阻塞性肺疾病、冠心病、糖尿病)。然而,除了两例与手术相关的死亡(肺栓塞n = 1,肺炎并发多器官功能衰竭n = 1)外,未观察到其他重大并发症。对于恶性淋巴瘤病例中的填充材料,就暴露时间而言可能具有致癌性,应在所有病例中取出。