Ross J K, Olsen E G
Thorax. 1976 Jun;31(3):324-31. doi: 10.1136/thx.31.3.324.
Between December 1964 and March 1969, 11 posterior cusp advancement operations were carried out for patients with mitral valve disease in whom there was posterior cusp deficiency. Seven of the nine long-term survivors have required reoperation for recurrent mitral regurgitation, combined in six instances with stenosis of varying severity, the interval between the first and second operations ranging from five months to nine years (average 57-5 months). Histological examination of the pericardial grafts recovered at re-operation has been made and shows that after an initial period during which the graft retains near normal structure, there is a progressive degeneration with fibrous tissue replacement. This process takes place on both surfaces of the graft where there is evidence of vascularization in the zone between the graft remnant and the overlying and increasingly thick fibrous tissue covering. The conclusion drawn from the experience with this small series is that the long-term performance of pericardial grafts designed to restore function to the posterior cusp of the mitral valve is poor and unpredictable.
1964年12月至1969年3月期间，对11例存在后叶瓣缺损的二尖瓣疾病患者进行了后叶瓣推进手术。9例长期存活者中有7例因二尖瓣反流复发需要再次手术，其中6例合并有不同程度的狭窄，首次手术与二次手术的间隔时间为5个月至9年（平均57.5个月）。对再次手术时取出的心包移植物进行了组织学检查，结果显示，在移植物保持接近正常结构的初始阶段过后，会逐渐发生变性，被纤维组织取代。这个过程发生在移植物的两个表面，在移植物残余部分与覆盖其上且日益增厚的纤维组织之间的区域有血管化的迹象。从这个小系列病例的经验得出的结论是，旨在恢复二尖瓣后叶瓣功能的心包移植物的长期性能较差且不可预测。
