Cossolini M, Ferri F, Giupponi A, Valoti O, Veritti U
II Servizio di Anestesia e Rianimazione, Azienda Ospedali Riunuti, Bergamo.
Minerva Anestesiol. 1997 Jun;63(6):213-9.
To evaluate the role of the phosphodiesterase inhibitor enoximone in low output states (LOS) following cardiac operations in congenital heart diseases.
This was an unblinded, retrospective, open study. Hemodynamic effects of intravenous enoximone were investigated in 130 patients--70 adults and 60 pediatrics--offered to our Department from 1992 to 1995. To avoid multifactorial events due to different cardiopathies, our analysis was limited to 24 newborns and children operated on for correction of tetralogy of Fallot (TOF).
Cardiac surgery ICU of a Regional Hospital in Italy.
Retrospective analysis of 24 cases of postoperative LOS in surgical corrected TOF, treated with enoximone, were compared with a control group treated with conventional inotropic drugs.
Data were compared by "t"-Student's test for impaired data.
Significative cardiac function improvement in treated group, demonstrated by an increased systemic pressure values, by decreased right chambers pressures and by significative improvement in oxygen mixed venous saturation. Better hemodynamic recovery after ICU discharge. No significant side effects were detected.
Enoximone is, suggested also in pediatric patients in the management of refractory LOS following open heart surgery, especially when a long-standing treatment is predictable (more than 72-96 hrs).
评估磷酸二酯酶抑制剂依诺昔酮在先天性心脏病心脏手术后低心排状态（LOS）中的作用。
这是一项非盲、回顾性、开放性研究。1992年至1995年期间，对我院收治的130例患者（70例成人和60例儿科患者）静脉注射依诺昔酮的血流动力学效应进行了研究。为避免因不同心脏病导致的多因素事件，我们的分析仅限于24例接受法洛四联症（TOF）矫正手术的新生儿和儿童。
意大利一家地区医院的心脏外科重症监护室。
对24例接受手术矫正TOF后出现术后LOS且接受依诺昔酮治疗的病例进行回顾性分析，并与接受传统强心药物治疗的对照组进行比较。
采用“t”检验对数据进行比较。
治疗组心脏功能显著改善，表现为体循环压力值升高、右心腔压力降低以及混合静脉血氧饱和度显著改善。重症监护病房出院后血流动力学恢复更好。未检测到明显副作用。
对于小儿患者，在心脏直视手术后难治性LOS的管理中也建议使用依诺昔酮，特别是当预计需要长期治疗（超过72 - 96小时）时。
