Secco G B, Fardelli R, Rovida S, Davini M D, Gianquinto D, Bonfante P
Istituto di Patologia Chirurgica, Università degli Studi, Genova.
Minerva Chir. 1997 Jul-Aug;52(7-8):875-83.
Short- and long-term results of the treatment of 54 patients (12.5%) with synchronous hepatic metastases were critically reviewed by means of retrospective analysis of 431 colorectal cancer patients surgically treated over a period ranging from January 1980 to December 1989. Incidence and stage of hepatic metastases (Gennari Classification, 1984) are not significantly correlated to stage (T3), grade (G2-G3) and mucinous colorectal tumours; but they are significantly correlated to metastatic lymph nodes (p < 0.01). Actuarial survival is significantly influenced by surgery (p < 0.01) and stage of liver metastases (p < 0.05). The restriction of preoperative exclusion criteria and the simultaneous surgical treatment of primary colorectal and secondary hepatic metastases seem to be responsible for the high rates of operative mortality.
通过对1980年1月至1989年12月期间接受手术治疗的431例结直肠癌患者进行回顾性分析，对54例（12.5%）伴有同步肝转移患者的治疗短期和长期结果进行了严格审查。肝转移的发生率和分期（Gennari分类，1984年）与分期（T3）、分级（G2 - G3）和黏液性结直肠癌肿瘤无显著相关性；但它们与转移性淋巴结显著相关（p < 0.01）。精算生存率受手术（p < 0.01）和肝转移分期（p < 0.05）的显著影响。术前排除标准的限制以及原发性结直肠癌和继发性肝转移的同期手术治疗似乎是导致手术死亡率高的原因。
