[Study of the Leiden mutation (factor VQ 506), the most frequent cause of thrombophilia, in 116 thrombosis patients].

The incidence of Leiden mutation was examined by PCR method in 116 thrombophilic patients in random fashion. Mean age at the first thrombotic episode was 30.97 years. 90 patients had positive family history for thrombosis, 67 had more than one thrombotic episodes. APC resistance with laboratory test was found in 51 cases (44%). F V Leiden mutation was proven in 44 patients (38%). 10 being homozygous and 34 heterozygous out of them.