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[肺部肿瘤学的当前主题]

[Current topics in pulmonary oncology].

作者信息

Sculier J P, Berghmans T, Vermylen P, Ninane V

机构信息

Service de Médecine, Institut Jules Bordet, Centre des Tumeurs de l'Université Libre de Bruxelles.

出版信息

Rev Med Brux. 1997 Sep;18(4):204-8.

PMID:9411643
Abstract

Thoracic oncology practice is changing with the end of the century. New diagnostic tools like photodetection allow to diagnose at a white light undetectable level. Preneoplastic lesions or very early cancers that can be locally treated by photochemotherapy, cryotherapy or brachytherapy. The natural history of lung cancer will also be better known. Concerning advanced disease, cisplatin chemotherapy improves survival of patients with stage III non-small cell lung cancer in combination with surgery or chest irradiation and of those with stage IV in comparison with best supportive care alone. New approaches in small cell lung cancer seem promising like accelerated chemotherapy, early chest radiotherapy and maintenance treatment. Moreover, a series of new active cytotoxic agents has been recently identified. The complexity of these modalities makes more and more necessary a integrated pluridisciplinary approach of the lung cancer patient.

摘要

随着世纪之交的到来,胸科肿瘤学实践正在发生变化。像光检测这样的新诊断工具能够在白光无法检测到的水平进行诊断。癌前病变或非常早期的癌症可以通过光化学疗法、冷冻疗法或近距离放射疗法进行局部治疗。肺癌的自然病史也将被更深入地了解。对于晚期疾病,顺铂化疗与手术或胸部放疗联合使用时可提高Ⅲ期非小细胞肺癌患者的生存率,与单纯最佳支持治疗相比,也可提高Ⅳ期患者的生存率。小细胞肺癌的新治疗方法似乎很有前景,如加速化疗、早期胸部放疗和维持治疗。此外,最近还发现了一系列新的活性细胞毒性药物。这些治疗方式的复杂性使得对肺癌患者采用综合多学科方法变得越来越必要。

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