脑腱黄瘤病中（23S）-5β-胆甾烷-3α，7α，12α，23，25-戊醇的鉴定
Identification of (23S)-5beta-cholestane-3alpha, 7alpha, 12alpha, 23, 25-pentol in cerebrotendinous xanthomatosis.
作者信息
Hoshita T, Yasuhara M, Kihira K, Kuramoto T
出版信息
Steroids. 1976 May;27(5):657-64. doi: 10.1016/s0039-128x(76)90160-4.
PMID:941184
Abstract
The synthesis of (23R)- and (23S)-5beta-cholestane-3alpha, 7alpha, 12alpha, 23, 25-pentols is described. Norcholyl aldehyde was converted into the cholestanepentols by a Reformatsky reaction with ethyl bromoacetate followed by a Grignard reaction with methylmagnesium iodide. One of the synthetic pentols, the 23S epimer was identical with a bile alcohol isolated from patients with cerebrotendinous xanthomatosis.
摘要
描述了(23R)-和(23S)-5β-胆甾烷-3α,7α,12α,23,25-戊醇的合成。通过与溴乙酸乙酯的Reformatsky反应，然后与甲基碘化镁的格氏反应，将降胆酰醛转化为胆甾烷戊醇。其中一种合成的戊醇，即23S差向异构体，与从脑腱性黄瘤病患者中分离出的一种胆汁醇相同。
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