Khotimichenko S A, Zhukova G F, Deryagina V P, Golubkina N A
Vopr Pitan. 1997(4):16-8.
The inhibiting effect of organic Se (selen-enriched yeast Bioselen) on the endogenous synthesis of N-nitrosubstances was investigated in the Wistar rats, receiving 15 mg of sodium nitritis and 24 mg of diethylamin per 1 kg of bodyweight during 22 days. The level of nitrosoprolin synthesis and (NPro) and the level of nitrosodiethyl (NDie) in the stomach of rats served as the main indices. The highest level of NPro and NDie were revealed in the rats, without selen supplementation (581.2 +/- 113.3 mg per kg of bodyweight and 29.8 +/- 3.0 mg per kg of bodyweight). The highest inhibiting effect of Se was 54.5% for NPro and 54.7% for NDie and it was shown for the Se concentration of 1.5 mg per 1 kg of forage. The increase of Se dosage to 3.0 mg per 1 kg of forage was less effective and resulted in 25.5% of inhibiting of NPro u 47.0% - NDie.
在Wistar大鼠中研究了有机硒（富硒酵母生物硒）对N-亚硝基物质内源性合成的抑制作用。这些大鼠在22天内每1千克体重接受15毫克亚硝酸钠和24毫克二乙胺。大鼠胃中亚硝基脯氨酸（NPro）的合成水平和亚硝基二乙胺（NDie）的水平作为主要指标。在未补充硒的大鼠中，NPro和NDie的水平最高（每千克体重分别为581.2±113.3毫克和29.8±3.0毫克）。对于每1千克饲料中硒浓度为1.5毫克的情况，硒对NPro的最高抑制作用为54.5%，对NDie的最高抑制作用为54.7%。将饲料中硒的剂量增加到每1千克饲料3.0毫克时效果较差，导致对NPro的抑制率为25.5%，对NDie的抑制率为47.0%。
