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[氢化可的松对输尿管上皮细胞增殖活性的影响]

[The effect of hydrocortisone on the proliferative activity ureteral epithelial cells].

作者信息

Dyban P A

出版信息

Tsitologiia. 1976 Jan;18(1):31-6.

PMID:941270
Abstract

Autoradiography has demonstrated that a single injection of hydrocortisone (10mg/100 gm b.w.) reduced statistically significant the number of DNA synthesizing cells and the intensity of 3H-thymidine incorporation in these cells, as well as reduced the number of mitotically dividing epithelial cells in the rat ureter. 16 hours after hydrocortisone administration, the amount of proliferating cells increases statistically, but in 48 hours it reaches the control level.

摘要

放射自显影术表明,单次注射氢化可的松(10毫克/100克体重)能显著减少DNA合成细胞的数量以及这些细胞中3H-胸腺嘧啶核苷的掺入强度,同时还能减少大鼠输尿管中有丝分裂的上皮细胞数量。给予氢化可的松16小时后,增殖细胞数量在统计学上有所增加,但在48小时后达到对照水平。

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