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[肌肉活动和休息期间骨骼肌纤维线粒体磷脂组成和功能状态的改变]

[Alteration of the phospholipid composition and functional state of skeletal muscle fiber mitochondria during muscular activity and rest].

作者信息

Leshkevich L G, Iakovlev N N

出版信息

Tsitologiia. 1976 Jan;18(1):41-7.

PMID:941272
Abstract

An intensive or prolonged muscular activity causes a decrease in mitochondrial phospholipid content (at the expence of phosphatidylcholine and phosphatidylethanolamine fractions) an augmented turnover of phosphate groups, a decrease of the optical density in mitochondria and the P/O ratio (at the expence of lowering of deltaP). During the recovery period, the content of phospholipids gradually restores: first phosphatidylethanolamine, and then phosphatidylcholine, a temporary increase in the amounts of polyglycerolphosphatide and acid phospholipids proceding. The augmentation of optical density of mitochondria and of P/O ratio over the inintial level coincides in time with the increase in acid phospholipid content. The enrichment of the animals diet with linoleic acid and methionine diminsihes biochemical changes caused by muscular activity in mitochondria to accelerate the normalization.

摘要

剧烈或长时间的肌肉活动会导致线粒体磷脂含量降低(以磷脂酰胆碱和磷脂酰乙醇胺部分为代价),磷酸基团周转增加,线粒体光密度降低以及P/O比值降低(以降低ΔP为代价)。在恢复期,磷脂含量逐渐恢复:首先是磷脂酰乙醇胺,然后是磷脂酰胆碱,同时会有聚甘油磷脂和酸性磷脂含量的暂时增加。线粒体光密度和P/O比值超过初始水平的增加与酸性磷脂含量的增加在时间上是一致的。用亚油酸和蛋氨酸丰富动物饮食可减少线粒体中肌肉活动引起的生化变化,从而加速恢复正常。

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