Beritashvili D R, Khariton V Iu, Chaĭlakhian L M
Tsitologiia. 1976 Jan;18(1):74-9.
Using frog muscle fibres, it is shown that 10(-6) tetrodotoxin does not practically affect the membrane permeability to lithium ions during a continious depolarization, with the membrane potential being near zero, but causes half a decreased lithium permeability under conditions of normal membrane potential. The absolute value of the lithium permeability for these two states are very close. A 10 mM tetraethylammonium chloride does not influence the lithium permeability of muscle membrane with the normal membrane potential and during a continious depolarization. It is proposed that intact and inactivated sodium channals may have almost equal ion passing capacities, but differ in their gate systems, especially as concerns its interaction with tetrodotoxin.
利用青蛙肌肉纤维进行的实验表明，在持续去极化过程中，当膜电位接近零时，10⁻⁶的河豚毒素实际上不会影响膜对锂离子的通透性，但在正常膜电位条件下会使锂通透性降低一半。这两种状态下锂通透性的绝对值非常接近。10 mM的四乙铵氯化物在正常膜电位和持续去极化过程中均不影响肌肉膜的锂通透性。研究提出，完整和失活的钠通道可能具有几乎相等的离子通过能力，但它们的门控系统不同，尤其是在与河豚毒素的相互作用方面。
