Sau G F, Aiello I, Siracusano S, Belgrano M, Pastorino M, Balsamo P, Magnano I, Rosati G
Clinica Neurologica, Università di Sassari, Italy.
Ital J Neurol Sci. 1997 Oct;18(5):289-91. doi: 10.1007/BF02083306.
Bladder dysfunctions are often observed in patients with multiple sclerosis (MS). In order to evaluate their sensitivity in detecting abnormalities in bladder central control pathways, pudendal nerve somatosensory evoked potentials (pSEPs) were recorded in 16 patients with clinically probable MS: six were affected by retention or urge incontinence, and ten were asymptomatic. Conventional visual, auditory and somatosensory evoked potentials were also recorded, and all of the patients underwent a urodynamic examination. Prolonged latency or the absence of pSEP cortical responses was found in eight of the ten asymptomatic patients, and in all of the symptomatic cases (87.5%). The urodynamic evaluation revealed abnormalities in 12 patients (75%). Our findings seem to indicate an early and frequent involvement of bladder control pathways in MS patients, as well as a high rate of subclinical disorders.
膀胱功能障碍在多发性硬化症（MS）患者中经常出现。为了评估其在检测膀胱中枢控制通路异常方面的敏感性，对16例临床疑似MS患者记录了阴部神经体感诱发电位（pSEP）：6例有尿潴留或急迫性尿失禁，10例无症状。还记录了传统的视觉、听觉和体感诱发电位，并且所有患者都接受了尿动力学检查。在10例无症状患者中有8例以及所有有症状病例（87.5%）发现pSEP皮质反应潜伏期延长或缺失。尿动力学评估显示12例患者（75%）存在异常。我们的研究结果似乎表明，MS患者的膀胱控制通路早期就频繁受累，并且亚临床疾病发生率很高。
