Van Kruiningen H J, Ganley L M, Freda B J
Department of Pathobiology, University of Connecticut, Storrs, USA.
J Clin Gastroenterol. 1997 Sep;25(2):470-5. doi: 10.1097/00004836-199709000-00017.
Recently researchers have suggested that clinical subsets of Crohn's disease occur, which are variously described as inflammatory, fibrostenotic, and fistulizing. In addition, it has been observed that within families with multiple cases, often there is concordance of the site and type of disease. The lesions of Crohn's disease occur in segments that suggest that distribution of Peyer's patches. When the age-related incidence of Crohn's disease was plotted for all countries from which such data were available, the peaks of greatest case frequency occurred at ages 15 to 25 years and paralleled a similar peak representing the number of Peyer's patches as a function of age. This correlation suggests that Crohn's disease may develop as an inflammatory process specifically targeting these important lymphoid structures. Similar peaks of activity in the adolescent to early adult years occur for appendicitis and tonsillitis.
最近，研究人员提出克罗恩病存在临床亚组，分别被描述为炎症型、纤维狭窄型和瘘管型。此外，据观察，在有多个病例的家庭中，疾病的部位和类型往往具有一致性。克罗恩病的病变发生在呈节段性分布的区域，提示与派尔集合淋巴结的分布有关。当绘制所有有此类数据的国家中克罗恩病的年龄相关发病率时，病例数最多的峰值出现在15至25岁之间，并且与派尔集合淋巴结数量随年龄变化的类似峰值平行。这种相关性表明，克罗恩病可能是作为一种特异性针对这些重要淋巴结构的炎症过程而发展的。阑尾炎和扁桃体炎在青少年到成年早期也会出现类似的活动高峰。
Zotero 插件