[在放线菌素D、四环素和环己酰亚胺影响下，抗坏血酸饱和的豚鼠组织中单胺氧化酶活性和儿茶酚胺含量的变化]
[Changes in monoamine oxidase activity and catecholamine content in the tissues of guinea pigs saturated with ascorbic acid under the influence of actinomycin D, tetracycline and cycloheximide].
作者信息
Lokoshko E A
出版信息
Ukr Biokhim Zh. 1976 Mar-Apr;48(2):153-7.
A short-time saturation of guinea pigs with ascorbic acid (100 mg per 1 kg of weight every hour for 5 h) causes its accumulation in the adrenals and blood, an increase in the monoaminooxidase activity in the liver and in the content of adrenaline in the adrenals. The content of noradrenaline in the liver and brain does not change. Inhibitors of protein synthesis, actinomycin D, tetracycline and cycloheximide, have a different effect on the increase in the monoaminooxidase activity evoked by introduction of ascorbic acid: tetracycline blocks the increase in the enzyme activity, actinomycin D has no effect on it. Cycloheximide introduced against a background of chronic saturation of guinea pigs with ascorbic acid also blocks the increase in the monoaminooxidase activity in the liver mitochondria.
用抗坏血酸对豚鼠进行短期饱和处理（每小时每千克体重100毫克，共5小时），会导致其在肾上腺和血液中积累，肝脏中单胺氧化酶活性增加，肾上腺中肾上腺素含量增加。肝脏和大脑中去甲肾上腺素的含量没有变化。蛋白质合成抑制剂放线菌素D、四环素和环己酰亚胺，对因引入抗坏血酸而引起的单胺氧化酶活性增加有不同影响：四环素会阻断酶活性的增加，放线菌素D对此没有影响。在豚鼠用抗坏血酸进行慢性饱和处理的背景下引入环己酰亚胺，也会阻断肝脏线粒体中单胺氧化酶活性的增加。
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