Ryan K L, Lovelace J D, Frei M R, Jauchem J R
Department of Biology, Trinity University, San Antonio, TX, USA.
Methods Find Exp Clin Pharmacol. 1997 Sep;19(7):455-64.
Sustained whole body exposure to 35-GHz radiofrequency radiation produces localized hyperthermia and hypotension, leading to circulatory failure and death. We previously demonstrated that pressor responses to nitric oxide (NO) synthesis inhibition are reduced following 35-GHz microwave (MMW) heating, implying that NO levels might also be reduced. This study therefore sought to determine whether administration of S-nitroso-N-acetylpenicillamine (SNAP), a NO donor, influences MMW-induced hypotension in ketamine-anesthetized rats. First, rats were exposed to MMW until mean arterial pressure (MAP) fell to 75 mmHg. MMW exposure was then discontinued and either SNAP (300 micrograms/kg/h) or saline was infused. SNAP infusion affected neither the hypotension nor the survival time following MMW exposure. In a second protocol, SNAP (300 micrograms/kg/h) or saline was infused prior to and throughout MMW exposure, which was continued until death. SNAP infusion did not alter either the onset or the magnitude of terminal hypotension. Therefore, we conclude that exogenous NO does not affect cardiovascular responses to 35-GHz MMW heating.
全身持续暴露于35吉赫兹的射频辐射会导致局部体温过高和低血压，进而引发循环衰竭和死亡。我们之前证明，在35吉赫兹微波（MMW）加热后，对一氧化氮（NO）合成抑制的升压反应会降低，这意味着NO水平可能也会降低。因此，本研究旨在确定给予NO供体S-亚硝基-N-乙酰青霉胺（SNAP）是否会影响氯胺酮麻醉大鼠中MMW诱导的低血压。首先，将大鼠暴露于MMW，直到平均动脉压（MAP）降至75毫米汞柱。然后停止MMW暴露，并输注SNAP（300微克/千克/小时）或生理盐水。输注SNAP对MMW暴露后的低血压和存活时间均无影响。在第二个方案中，在MMW暴露之前及整个过程中输注SNAP（300微克/千克/小时）或生理盐水，持续暴露直至死亡。输注SNAP既未改变终末期低血压的起始时间，也未改变其严重程度。因此，我们得出结论，外源性NO不会影响对35吉赫兹MMW加热的心血管反应。
