一名患有沃纳综合征患者的24小时生长激素分泌情况。
Twenty-four hour growth hormone secretion in a patient with Werner's syndrome.
作者信息
Rubin C D, Reed B
机构信息
Department of Internal Medicine, University of Texas Southwestern Medical Center at Dallas 75235-8889, USA.
出版信息
Exp Gerontol. 1996 Sep-Oct;31(5):557-61. doi: 10.1016/0531-5565(96)00031-9.
OBJECTIVE
To assess the 24-h endogenous secretory growth hormone (GH) profile and serum insulin-like growth factor-I (IGF-I) response to exogenous recombinant human growth hormone (rhGH) in a patient with Werner's syndrome.
DESIGN
Blood sampling every 20 min for 24 h followed by three daily injections of growth hormone.
SETTING
General Clinical Research Center.
PATIENTS
Single patient with Werner's syndrome.
MEASUREMENTS
Serum GH and IGF-I.
RESULTS
Growth hormone pulses were absent during the 24-h monitoring period. Likewise, integrated GH concentrations were very low at 0.25 mu min/mL, and no peaks occurred after sleep onset. Following single daily administration of rhGH, serum GH and IGF-I rose.
CONCLUSIONS
Our findings support previous but less extensive studies suggesting patients with Werner's syndrome have reduced growth hormone levels. Preliminary investigations using rhGH in patients with Werner's syndrome should be considered.
目的
评估一名沃纳综合征患者24小时内源性分泌生长激素（GH）谱以及血清胰岛素样生长因子-I（IGF-I）对外源性重组人生长激素（rhGH）的反应。
设计
每20分钟采血一次，持续24小时，随后每日注射三次生长激素。
地点
综合临床研究中心。
患者
一名沃纳综合征患者。
测量指标
血清GH和IGF-I。
结果
在24小时监测期内未出现生长激素脉冲。同样，整合的GH浓度非常低，为0.25 μU/min/mL，入睡后未出现峰值。每日单次给予rhGH后，血清GH和IGF-I升高。
结论
我们的研究结果支持先前但不太广泛的研究，表明沃纳综合征患者的生长激素水平降低。应考虑对沃纳综合征患者使用rhGH进行初步研究。
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