Tokuhashi Y, Kikkawa F, Ishikawa H, Tamakoshi K, Hattori S, Matsuzawa K, Inoue T, Suganuma N, Tomoda Y
Department of Obstetrics and Gynecology, Nagoya University School of Medicine, Japan.
Gynecol Obstet Invest. 1997;44(4):270-4. doi: 10.1159/000291542.
Defining tissue accumulation of platinum may be of importance, since it may provide a pharmacological explanation for organ-specific cisplatin activity. This study was conducted to evaluate the efficacy of cisplatin at the tissue level in different gynecologic organs. The doses administered were equivalent to those used in neoadjuvant chemotherapy regimens.
Cisplatin was administered intravenously to patients with cervical or endometrial cancer 1 h before operation, and platinum accumulations in tissues were assayed by the atomic absorption method.
Platinum accumulation was highest in the cervix and next highest in the myometrium in both cancers. Platinum accumulation in ovary and lymph node was only 0.58 and 0.57 times that in the myometrium, respectively. In patients with cervical cancer, the platinum accumulations in the myometrium and cervix were significantly higher than in the ovary and lymph node. Platinum accumulation in cervical cancer tissue was lower than in the myometrium and cervix, suggesting that delivery of cisplatin to a cervical cancer is somewhat more difficult than to the normal cervix. In patients with endometrial cancer, there was significantly more accumulation in the cervix than in the ovary and lymph node.
These data indicated that cisplatin was easily distributed to the cervix and myometrium, but not to the ovary, lymph node, and cancer tissues.
确定铂在组织中的蓄积情况可能具有重要意义，因为这可能为顺铂的器官特异性活性提供药理学解释。本研究旨在评估顺铂在不同妇科器官组织水平的疗效。给药剂量与新辅助化疗方案中使用的剂量相当。
在手术前1小时对宫颈癌或子宫内膜癌患者静脉注射顺铂，并用原子吸收法测定组织中的铂蓄积量。
在两种癌症中，铂蓄积量在宫颈中最高，在子宫肌层中次之。卵巢和淋巴结中的铂蓄积量分别仅为子宫肌层的0.58倍和0.57倍。在宫颈癌患者中，子宫肌层和宫颈中的铂蓄积量显著高于卵巢和淋巴结。宫颈癌组织中的铂蓄积量低于子宫肌层和宫颈，这表明将顺铂递送至宫颈癌组织比递送至正常宫颈组织稍难。在子宫内膜癌患者中，宫颈中的蓄积量显著高于卵巢和淋巴结。
这些数据表明，顺铂易于分布到宫颈和子宫肌层，但不易分布到卵巢、淋巴结和癌组织。
