Raj D S, D'Mello S, Somiah S, Sheeba S D, Mani K
Department of Nephrology, St. John's Medical College Hospital, Bangalore, India.
Ren Fail. 1997 Nov;19(6):799-806. doi: 10.3109/08860229709037220.
M-mode, two-dimensional, and Doppler echocardiography were performed in 38 chronic renal failure (CRD) patients on conservative management, 35 patients on hemodialysis, and 36 matched controls. The controls were matched for age, sex, and comorbidities. The incidence of hypertension, left ventricular (LV) end diastolic volume, LV end systolic volume, and LV mass index were significantly higher in patients on hemodialysis compared to the controls. The LV parameters in the predialysis patients were not significantly different from the controls, except the LV end systolic internal dimensions were significantly higher in the CRF patients. Multiple regression analysis underscored the strong association between increase in LV mass index (LVMI) and hypertension. The diabetic patients with renal failure had large LV internal diameter and end diastolic volume compared to non-diabetics. Systolic function was well preserved even in hypertensive and diabetic patients with uremia. The incidence of diastolic dysfunction and asymmetrical septal hypertrophy were not significantly different in the three groups of patients.
对38例接受保守治疗的慢性肾衰竭(CRD)患者、35例接受血液透析的患者以及36例匹配的对照组进行了M型、二维和多普勒超声心动图检查。对照组在年龄、性别和合并症方面进行了匹配。与对照组相比,接受血液透析的患者高血压发病率、左心室(LV)舒张末期容积、LV收缩末期容积和LV质量指数显著更高。除了CRF患者的LV收缩末期内径显著更高外,透析前患者的LV参数与对照组无显著差异。多元回归分析强调了LV质量指数(LVMI)增加与高血压之间的强烈关联。与非糖尿病患者相比,糖尿病肾衰竭患者的LV内径和舒张末期容积更大。即使在患有尿毒症的高血压和糖尿病患者中,收缩功能也得到了很好的保留。三组患者舒张功能障碍和不对称性室间隔肥厚的发生率无显著差异。