Krieg D, Weigl E, Bach H
Acta Hepatogastroenterol (Stuttg). 1976 Jun;23(3):168-72.
The morbidity by viral hepatitis within the municipal and rural district of Eisenhüttenstadt with 66 211 inhabitants from 1960 t0 1970 amounts to 19.45 +/- 1.06%. The transition into chronic hepatitis appears in 5.5 per cent in 1 283 controlled cases of illness. Contrary to the acute viral hepatitis the numbers of illness by chronic hepatitis are increasing with proceeding age (0.3 per cent up to 14 per cent). The prognosis of viral hepatitis is altogether favorable. 84.1 per cent are healing completely primarily without any subsequences and 4.4 per cent are followed by defective states. The chronic persisting hepatitis heals in more than the half of the cases, mostly after a duration of two till five years of illness. The tendency to heal is significantly stronger in children and adolescents than in adults. The chronic aggressive hepatitis has an unfavorable prognosis. In the development of the cirrhosis of the liver (0.5 per cent) additional noxes are playing a role. The alcohol shows an unfavorable influence on the course of the illness (0.7 per cent). A hyperbilirubinemia does not appear essentially more frequently than in the normal population. The prospective character of the study in not selected patients imparts to these findings a real epidemiological sentential power.
在拥有66211名居民的艾森许滕施塔特市市区及农村地区，1960年至1970年期间病毒性肝炎的发病率为19.45±1.06%。在1283例确诊病例中，5.5%转变为慢性肝炎。与急性病毒性肝炎不同，慢性肝炎的发病数量随年龄增长而增加（从0.3%增至14%）。病毒性肝炎的总体预后良好。84.1%的患者最初完全康复且无任何后遗症，4.4%的患者随后出现功能缺陷状态。超过半数的慢性持续性肝炎患者会康复，多数在患病两至五年后。儿童和青少年的康复倾向明显强于成年人。慢性侵袭性肝炎预后不佳。在肝硬化的发展过程中（0.5%），其他有害因素也起作用。酒精对病程有不良影响（0.7%）。高胆红素血症的出现频率与正常人群相比并无显著增加。对未经过挑选的患者进行的前瞻性研究赋予了这些发现真正的流行病学意义。
