Yamaguchi M, Yamada T, Kinoshita I, Wu S, Nagashima T, Tamaki N
Faculty of Health Science, Kobe University School of Medicine, Japan.
Acta Neurochir Suppl. 1997;70:152-4. doi: 10.1007/978-3-7091-6837-0_46.
Brain edema is an important clinical condition. Pathophysiological findings on behavioral changes may be helpful for a comprehensive understanding of brain edema. However, only few reports on behavioral studies of brain edema have so far appeared. Experiments using psychological techniques on animals are rather time-consuming and may not be suitable for the study of transient conditions, as brain edema caused by trauma, vascular accidents, or others. We have developed a method for avoidance learning of rats using a running wheel apparatus with computer assistance. This model was employed in studies on brain edema from water introxication in rats. As a result, avoidance learning was significantly impaired by water intoxication. Either direct overhydration of the brain or indirect effects, as a decrease in cerebral blood flow, or both, are suggested as mechanisms underlying the impairment of behavior.
脑水肿是一种重要的临床病症。行为变化方面的病理生理学发现可能有助于全面理解脑水肿。然而，迄今为止，关于脑水肿行为学研究的报道很少。在动物身上使用心理学技术进行实验相当耗时，可能不适用于研究诸如创伤、血管意外或其他原因引起的脑水肿等短暂性病症。我们开发了一种借助计算机辅助的跑步轮装置对大鼠进行回避学习的方法。该模型被用于大鼠水中毒所致脑水肿的研究。结果发现，水中毒会显著损害回避学习能力。大脑直接过度水化或间接影响（如脑血流量减少）或两者兼而有之，被认为是行为受损的潜在机制。
