Rothman D, Allen H, Herzog L, Pilapil A, Seiler C M, Zurier R B
Rheumatology Division, Department of Medicine, University of Massachusetts Medical Center, Worcester, MA 01655-0335, USA.
Cytokine. 1997 Dec;9(12):1008-12. doi: 10.1006/cyto.1997.0304.
Dihomogammalinolenic acid is derived from gammalinolenic acid, administration of which suppresses joint inflammation. It is reported here that interleukin 1beta (IL-1beta) production by human monocytes is enhanced markedly when cells are incubated 18-24 h with the polyunsaturated fatty acids dihomogammalinolenic acid (DGLA) and arachidonic acid (AA), then stimulated with lipopolysaccharide. Effects of eicosapentaenoic acid (EPA) on IL-1beta production are minimal, and palmitic acid (PA) does not influence IL-1beta production.
二高-γ-亚麻酸由γ-亚麻酸衍生而来，γ-亚麻酸的施用可抑制关节炎症。本文报道，当人单核细胞与多不饱和脂肪酸二高-γ-亚麻酸（DGLA）和花生四烯酸（AA）孵育18 - 24小时，然后用脂多糖刺激时，其白细胞介素1β（IL-1β）的产生会显著增强。二十碳五烯酸（EPA）对IL-1β产生的影响极小，而棕榈酸（PA）不影响IL-1β的产生。
